Dehyroepiandrosterone (DHEA) is a C19 steroid produced in the adrenal cortex and to a lesser extent in the gonads. DHEA serves as precursor in testosterone and estrogen synthesis. Due to the presence of a 17-oxo-group, DHEA has relatively weak androgenic activity, which has been estimated at ~10% that of testosterone. However in neonates, peripubertal children and in adult women, circulating DHEA levels may be several fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgen (androstenedione and testosterone) and estrogen may occur. Moreover, DHEA has relatively low affinity for sex-hormone binding globulin. These factors may enhance the physiologic biopotency of DHEA.