DHEAS is one the most abundant circulating steroids. It is produced by the adrenal and gonads. As a result, the determination of the level of DHEAS in serum is important in the evaluation of the functional state of these glands. It is also a precursor of testosterone and estrone. Besides the adrenals, in females, the ovaries have been shown to be an important source of DHEAS.
It has been reported that there is a ﬂ uctuation day by day of DHEAS in women during the ovulatory cycle.
The principal production of testosterone in females is from the conversion of other related androgens especially DHEAS. An abnormal testosterone levels in women should be ac-companied by the estimation of serum DHEAS. The use of serum testosterone determination in conjunction with DHEAS can be used to determine if the source of excess androgen production is ovarian or adrenal.