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- USA: For Research Use Only. Not for diagnostic purposes.
Estrone is a steroid like estriol and estradiol, belonging to the class of estrogens. The estrogens are involved in the development of female sex organs and secondary sex characteristics. Before the ovum is fertilized the main action of the estrogens is on the growth and function of the reproductive tract in order to prepare it for the fertilized ovum.
During the follicular phase of the menstrual cycle the estrone level shows a slight increase. The production of estrone then increases markedly to peak at around day 13 of the cycle. The peak is of short duration and by day 16 of the cycle levels will be low. A second peak occurs at around day 21 of the cycle and if fertilization does not occur, then the production of estrone decreases. The measurement of estrone is useful for monitoring ovarian function, in predicting ovulation, in assessing the effect of therapy to induce ovulation.
The measurement of estrone in saliva is an attractive alternative to plasma analysis because its non-invasive, stress-free procedure makes serial sampling easy. Some research appears to confirm that estrone concentrations in saliva approximate the unbound-estrone in plasma therefore provide a more accurate indication of endocrine activity.