B2-Microglobulin ELISA kit
Ref CAN-B-4300
Kit Type: Competitive ELISA
Kit Size: 96-well break-apart microplate
Sensitivity: 0.1 mg/L
Sample Type: Human serum / 20 μL
Calibrator Range: 0.2–10 mg/L
Total Assay Time: 80 minutes
Note: When using the kit, the IFU version that is provided with the kit must be followed.
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  • CAN: IVD
  • EU: IVD 
  • USA: For Research Use Only. Not For Use In Diagnostic Procedures.

β2-Microglobulin (β2-M) is a single polypeptide chain containing 100 amino acids and is found on the surface of nucleated cells. β2-M is continuously secreted into the circulatory system and therefore maintains a balanced serum level.

Clinical Trends:

  • Decreases in the glomerular filtration rate gives rise to increases in the level of β2-M.
  • β2-M is a helpful marker in the diagnosis of kidney disease and active rheumatoid arthritis.
  • Patients with acquired immune deficiency syndrome (AIDS) show an increased level of β2-M.

β2-M has a low concentration in serum. We have found in a normal unselected population that in serum the highest level for β2-M is 3.8 mg/L. The total number of serum samples tested was 92, showing little differences in the normal level in males, pre- and postmenopausal females. The average for male samples = 1.582 mg/L, for premenopausal female = 1.457 mg/L, for postmenopausal female = 1.608 mg/L and finally for young people = 1.13 mg/L.

Medical applications