DBC Sex Hormone Binding Globulin (SHBG) ELISA kit, kit image, silhouette of a pipette
Ref CAN-SHBG-4010
Kit Type: Sandwich ELISA
Kit Size: 96-well break-apart microplate
Sensitivity: 0.1 nmol/L
Sample Type: Human serum / 10 μL
Calibrator Range: 3.3–295 nmol/L
Total Assay Time: 60 minutes
Note: When using the kit, the IFU version that is provided with the kit must be followed.
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  • CAN: IVD
  • EU: IVD CE
  • USA: For Research Use Only. Not For Use In Diagnostic Procedures.

Sex hormone binding globulin (SHBG) is a glycoprotein composed of 373 amino acid residues and three carbohydrate side chains. SHBG has been known by many other names including Testosterone-estradiol Binding Globulin (TeBG), Sex steroid Binding Protein (sBP) and Sex Steroid Binding Globulin (SSBG). One of the main properties of SHBG is its high affinity for steroids, especially the C18, C19 and 17α-hydroxyl groups. The binding of steroids to SHBG is temperature and pH dependent. The three steroids that have a high avidity for SHBG are Dihydrotestosterone, Testosterone and Estradiol. Very small amounts of these steroids are free in biological fluid; the majority are bound to SHBG and albumin. These two fractions, that is, free and bound exist in a state of dynamic equilibrium. When the level of SHBG concentration changes, a remarkable change occurs in both albumin-bound hormone and also in the free fraction.

Medical applications